Thierry Frémaux tried once before to ban the "ridiculous and grotesque" practice at the world's most prestigious film festival in 2015, before backing down.
Instead he pleaded with filmgoers, who are usually dressed to the nines in tuxedos and evening gowns, to contain themselves as much as they could.
But this time there would be no reprieve, he said.
"Selfies will be banned for spectators on the red carpet," Frémaux told the Film Français magazine. But it was unclear whether the ban will also apply to the cast and crew of the films being shown.
"The triviality and slowdown caused by the unwanted disorder created by the practice of selfies harms the quality of the climb up the steps, and so the entire festival," he added.
Hollywood stars have also been known to take selfies of themselves on the Cannes red carpet.
Frémaux also raised the hackles of some film critics with major changes to the timings of press screenings, which were traditionally held before the gala red carpet premieres in the evenings.
But critics will now have to wait for the next morning to see half of the films in the main competition, while others will be shown at the same time.
The Guardian's critic Peter Bradshaw led the revolt against the move, tweeting, "Whoa! Why not just have an embargo? Is it that hard to enforce?
"I can't help thinking Cannes is saving up grief for itself with this!"
Variety's Guy Lodge warned that some critics would inevitably be shut out of the evening screening.
He said that the rival Berlin film festival "successfully enforces an embargo between morning press screenings and evening premieres. Critics get more time to write more considered reviews, and the films don't get their buzz stomped on. Everybody wins. Why can't Cannes do this?"
Cannes has always been notorious for the reaction of the critics, with some booing films, which can damage their prospects long before they are released.
Lodge said the change would ultimately lead to publicists showing films to select critics ahead of time -- "not quite the great leveller that Frémaux has in mind".
The festival's director had earlier hinted to Screen magazine that a major change was in the offing.
"Don't you think that it could be better to have the press screening and the gala screening in the same day, in the same moment, in the same hour, in order for the film team to arrive in total innocence, to make both the gala screening and the press screening two big world events?" he said.
- with AFP