Over 100 demonstrations have been planned across the country in favour of better pay, improved purchasing power, retirement protection, gender equality and a fairer education system.
Unions, students, political parties expected
The CGT, Force Ouvrière, Solidaires and student unions Unef and UNL hope their demonstration will put further pressure on President Emmanuel Macron, who is expected to put forward propositions in response to the Yellow Vest crisis in the coming weeks.
The French communist party also declared it would take part in today's action.
National Education, transport and garbage collection are expected to be affected by the strike.
Four out of ten primary school teachers are expected to be absent to protest against recent education policies.
They are concerned there will not be enough staff to handle the government directive which states children must be enrolled in school at three years of age.
In Paris, protesters will march from Boulevard Saint-Michel to the Champ-de-Mars from around 1300GMT, with Philippe Martinez at the head of the CGT and Yves Veyrier, secretary of the Force ouvrière (FO).
"There has been positive feedback. Some of the groups who don't protest readily are joining us this time", Veyrier told Reuters news agency.
Essential issues overshadowed
The FO regrets however, that the biggest union, the CFDT, has decided not to join the strike. Its leader, Laurent Berger told France Culture radio that "we (the union) don't really know what their main motivation is".
It's the first interprofessional strike since October 9th and is expected to have a bigger turnout than the previous demonstration organised by the CGT on the 5 February where some 137,200 people turned out according to the Interior Ministry.
At that occasion, they were joined by yellow vest protesters, finding common ground on some issues. But despite this, the CGT and the FO chose to boycot the Grand National Debate, organised by President Emmanuel Macron.
The CGT and the FO feel they have been left on the sidelines, overshadowed by the yellow vest demands, and the violent scenes during protests.
The CGT has said it wants to put the debate "back where it should be", meaning action inside companies as well as in the streets.
For Yves Veyrier, interviewed by RFI French service "violence is admitting a weakness. We want to protest calmly."
"The trade unions can't sit back silently like spectators, in this current context..."
"It's time to oblige employers to sit down at the table" he insists.
"We were hosted by the Elysées (palace) on 10 December...but the answers given did not address the essential issues such as salaries," he concluded.
The government is due to present its propositions in mid April, based on conclusions drawn from the Grand National Debate which wrapped up on the 15 March.