The Green Bay Packers, already well aware of how difficult it is to face Drew Brees, are now learning what life is like without Aaron Rodgers.
The 38-year-old American Brees threw his 500th career NFL touchdown on Sunday as he continued his dominance over the Packers, leading the New Orleans Saints to a 26-17 victory.
"Keep your eyes on the prize and focus on the process and know that good things will happen," said Brees, who compiled a total of 331 passing yards on 27-of-38 completions.
Brees has now surpassed 300 passing yards in all seven of his career games against the Packers.
Green Bay quarterback Brett Hundley completed just 12 of 25 for 87 yards in his first start in place of Rodgers, who could miss the rest of the season after suffering a broken right collarbone last week.
Hundley didn't make any major blunders, but he also didn't engineer any game-breaking plays.
Head coach Mike McCarthy accepted the blame for the loss.
"Our passing game, we can sit here and pick it apart all we want," McCarthy said. "Let's just blame it on the head coach today."
Elsewhere, the upstart Los Angeles Rams continued their winning ways with a 33-0 beatdown of the Arizona Cardinals, who lost star quarterback Carson Palmer with a broken arm.
Jared Goff threw for 235 yards and a touchdown in front of a crowd of 73,700 at London's Twickenham Stadium and Todd Gurley had his fourth game of 100 or more rushing yards.
Palmer exited the game in the second quarter with a broken left arm and will be out at least eight weeks and possibly the rest of the season.
Greg Zuerlein added four field goals for the Rams. Gurley rushed for 106 yards and a touchdown on 22 carries. It was Gurley's fourth 100 yards-plus game this season.
In Chicago, Bears rookie safety Eddie Jackson became the first player in NFL history to score two defensive touchdowns of at least 75 yards in the same game in his team's 17-3 upset of the Carolina Panthers.
Although the Panthers offense dominated, Jackson's fumble return during the game's first series and his interception and TD return of a pass from Panthers quarterback Cam Newton in the second quarter buoyed the Bears.
"I thought our defense played lights out today," Bears tight end Zach Miller said. "Put points un the board for us, really took control of that game and got the victory for us."
- Boot camp -
The day also belonged to kickers, including Kai Forbath who booted a half-dozen field goals as the Minnesota Vikings won their third straight with a 24-16 victory over the Baltimore Ravens.
It marked the fourth loss in five games for the Ravens in a game dominated by defence on both sides. The teams combined for just two touchdowns, and the Vikings sacked Baltimore quarterback Joe Flacco five times.
In Cleveland, kicker Ryan Succop scored all of Tennessee's points and capped his four-field goal game with a 47-yard kick with 1:55 left in overtime to give the Titans a 12-9 victory over the Browns.
A 54-yard field goal by Browns rookie kicker Zane Gonzalez with 47 seconds left in regulation tied the score 9-9.